The Effects of Low Concentrations of Pravastatin on Placental Cells

• DOI: 10.1007/s43032-024-01611-x
• Publication Date: 2024-06-05T15:01:59Z
• Authors: Masako Kanda; Keiichi Kumasawa; Kazunari Nemoto; Risa Miyatake; Kei Inaba; Seisuke Sayama; Takahiro Seyama; Takayuki Iriyama; Takeshi Nagamatsu; Tomoyuki Fujii; Yasushi Hirota; Yutaka Osuga; Tadashi Kimura
• Keywords: Spiral artery; Trophoblast; Cytotrophoblast

Abstract Pravastatin is a promising medication to treat preeclampsia. However, the appropriate dose of pravastatin for managing preeclampsia has not been established. In this in vitro study, we examined effects low concentrations (0.01 10 µM) under hypoxic conditions on two types placental cells and found that decreased sFlt-1 levels up 34% cytotrophoblast isolated from human term placentas. Furthermore, showed HTR-8/SVneo cells, cell line derived first trimester trophoblast after exposure very (0.01, 0.1 µM). We also uterine spiral artery remodeling-related events wound healing tube formation assays upregulated migration invasion cells. These results demonstrated suggest potential anti-preeclamptic vivo.