Fast-acting antidepressant-like effects of ketamine in aged male rats
Male
Aging
Hippocampus* / metabolism
Prefrontal Cortex
TOR Serine-Threonine Kinases / metabolism
Prefrontal Cortex* / metabolism
Hippocampus
03 medical and health sciences
0302 clinical medicine
Animals
Brain-Derived Neurotrophic Factor* / metabolism
Rats, Wistar
Antidepressive Agents* / pharmacology
Swimming
Aging* / drug effects
Cell Proliferation
Depression
Research
Brain-Derived Neurotrophic Factor
TOR Serine-Threonine Kinases
Depression / metabolism
Depression / drug therapy
Antidepressive Agents
Rats
Hippocampus* / drug effects
Cell Proliferation / drug effects
Ketamine
Prefrontal Cortex* / drug effects
Ketamine* / pharmacology
DOI:
10.1007/s43440-024-00636-y
Publication Date:
2024-08-19T06:40:19Z
AUTHORS (4)
ABSTRACT
Abstract Background The aging process causes anatomical and physiological changes that predispose to the development of late-life depression while reduces efficacy classical antidepressants. Novel fast-acting antidepressants such as ketamine might be good candidates explored in context aging, especially given lack previous research on its for this age period. Thus, aim present study was characterize ketamine’s effects older rats. Methods (30 min) repeated (7 days) antidepressant-like (5 mg/kg, ip ) were evaluated 14-month-old single-housed rats through forced-swim novelty-suppressed feeding tests. In parallel, modulation neurotrophic-related proteins (i.e., mBDNF, mTOR, GSK3) assessed brain regions affected by process, prefrontal cortex hippocampus, well possible hippocampal cell proliferation. Results Acute induced a response male aged rats, observed reduced immobility test, parallel with region-specific increase mBDNF protein content cortex. However, failed induce efficacy, but decreased rate proliferation and/or other markers not modulated either paradigm ketamine. Conclusions These results complement prior data supporting effect further extend ages. Future studies are needed clarify after treatment potential adverse aging.
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