Incidence Trends of Inherited Anemias at the Global, Regional, and National Levels Over Three Decades

• DOI: 10.1007/s44197-023-00170-9
• Publication Date: 2023-12-11T13:02:33Z
• Authors: Hongwei Tang; Nan Zhang; Xinlei Liu; Hongbo Xiao; Hanyue Zhang; Kang Zhou; Jianchuan Deng
• Keywords: Sickle cell trait; Trait

Abstract Inherited anemia continues to pose a significant public health concern on global scale, owing its extensive geographical prevalence, substantial patient population, and profound ramifications. Here, we investigated detailed information inherited anemias (including thalassemias, thalassemias trait, sickle cell disease, G6PD deficiency, trait) for the period 1990–2019 from Global Burden of Disease study. Over course three decades, there has been persistent rise in incidence worldwide, culminating total 44,896,026 incident cases 2019. However, prevalence exhibited consistent downward trend over successive years. Significantly, these primarily impact females, exhibiting male-to-female ratio 1:1.88. Among males, most prevalent is whereas trait prevails among females. The rates their temporal variations across different regions, with Central Sub-Saharan Africa displaying highest Latin America experiencing decline. findings this study suggest correlation between Socio-Demographic index (SDI) anemias, particularly regions lower SDI levels such as South Asia. These results contribute valuable insights analysis trends burden anemias.