Guideline of precisional testing in intrahepatic cholangiocarcinoma: an international expert consensus

• DOI: 10.1007/s44272-025-00036-0
• Publication Date: 2025-05-20T09:44:33Z
• Authors: Xin Zhang; Jing Han; Ruoyu Shi; Bing Yu; Xuchen Zhang; Bin Li; Xia Sheng; Zengshan Li; Yining Zou; Huichuan Sun; Guoming Shi; Hanlin L. Wang; Jian Zhou; Jia Fan; Wenming Cong; Yuan Ji

Abstract Intrahepatic cholangiocarcinoma (ICC) is a highly heterogeneous tumor. Molecular profiling serves as the foundation for personalized treatment of ICC. Comprehensive molecular testing is needed to identify more patients that are suitable for specific targeted therapies. This consensus is based on clinical data from both domestic and international sources, tailored to the Chinese context, and focuses on key targets for ICC. We present 15 recommendations aimed at guiding the precision detection of ICC.