Multiple Loss of Heterozygosity in a Case of Rare Ovarian Mixed Germ Cell Tumor - Case Report and Overview of Literature

• DOI: 10.1007/s44411-025-00026-7
• Publication Date: 2025-01-27T12:22:30Z
• Authors: Juraj Hutník; Petra Priščáková; Vanda Repiská; Miroslav Korbeľ; Ľudovít Danihel; Jozef Šufliarsky; Michaela Kubičková; Lajos Gergely
• Keywords: Ovarian tumor

Abstract Malignant germ cell tumors (GCTs) are characterized by pluripotency and exhibit diverse embryonic extraembryonic structures. Approximately 10% of malignant GCTs mixed tumors. The precise histogenic origins remain elusive, mostly because their rare occurrence. aim this study is to determine the origin an extremely tumor ovary consisting embryonal carcinoma non-gestational choriocarcinoma components using short tandem repeats genotyping quantitative-fluorescence PCR capillary electrophoresis. comparison repeat profiles between patient's blood DNA microdissected revealed a consistent loss heterozygosity at multiple loci, indicating clonal for both suggesting potential in abnormal meiotic processes. presence vast majority examined loci suggests from aberrant meiosis, possibly due errors meiosis I or II. Due rarity tumors, it difficult assess clinical significance exact origin. Further studies meta-analyses larger cohort next essential step explore GCT origins. This article aims improve understanding etiology.