Characterization of Gut Microbiota Composition in Colorectal Adenoma and Carcinoma Patients Compared to Healthy Controls

• DOI: 10.1007/s44411-025-00177-7
• Publication Date: 2025-05-15T08:23:00Z
• Authors: Lenka Wachsmannová; Silvia Dulanská; Miloslav Karhánek; Viola Števurková; Soňa Čierniková; Vanda Repiská; Jakub Styk; Katarína Šoltys; Michal Trnka
• Keywords: Colorectal adenoma

Abstract In this study, we aimed to elucidate the role of gut microbiome in multistage progression colorectal cancer (CRC). We analyse bacterial composition three clinical groups: healthy individuals, patients with precancerous polyps (adenomas), and cancerous tumours (carcinomas). Biopsy samples were profiled using Illumina MiSeq platform. Significant differences microbiota emerged between groups. The tumour-associated showed increased diversity specific enrichments, including Verrucomicrobia (genus Akkermansia) Bacteroidetes (genera Porphyromonas Prevotella). contrast, group exhibited a higher abundance protobacteria Microvirga). particular, adenoma also elevated levels bacteria compared control group. Our findings suggest possible link CRC, variations observed at different stages disease. This opens avenues for further investigation potential as biomarker therapeutic target prevention management.