Dopaminergic stimulation up‐regulates the in vivo expression of brain‐derived neurotrophic factor (BDNF) in the striatum

• DOI: 10.1016/0014-5793(92)81430-t
• Publication Date: 2002-07-25T07:42:02Z
• Authors: Hitoshi Okazawa; Miho Murata; Masahiko Watanabe; Masaki Kamei; Ichiro Kanazawa
• Keywords: Mice, Inbred BALB C; 0303 health sciences; Base Sequence; Dopamine; Brain-Derived Neurotrophic Factor; Dopamine Agents; Molecular Sequence Data; Nerve Tissue Proteins; Brain-derived neurotrophic factor; Corpus Striatum; Striatum; Up-Regulation; Mice; 03 medical and health sciences; Animals; Amino Acid Sequence; Nerve Growth Factors; Transcription

We investigated the effect of dopamine on in vivo expression brain‐derived neurotrophic factor (BDNF) striatum mouse. BDNF mRNA striation, which was Quantified with reverse transcriptase polymerase chain reaction, up‐repulated from 2 h after oral administration levodopa, a precursor dopamine. The increase sustained for 16 h. Co‐administrstion haloperidol partially inhibited dopamine‐induced enhancement. These data suggest that dopaminergic stimulation directly promotes vivo.