Interleukin‐10 inhibits endotoxin‐induced tissue factor mRNA production by human monocytes

• DOI: 10.1016/0014-5793(93)81693-t
• Publication Date: 2002-07-25T07:41:36Z
• Authors: M. Ramani; V. Ollivier; F. Khechai; T. Vu; C. Ternisien; F. Bridey; D. de Prost
• Keywords: Lipopolysaccharides; 0301 basic medicine; In Vitro Techniques; Monocyte; Tissue factor; Monocytes; Interleukin-10; Thromboplastin; 3. Good health; Kinetics; 03 medical and health sciences; Endotoxin; Humans; RNA, Messenger

In Gram‐negative septic shock, human monocytes synthesize and express on their cytoplasmic membrane tissue factor (TF), a potent activator of the coagulation cascades. The role of TF in triggering disseminated intravascular coagulation (DIC) in these patients appears to be clear. We report the suppressive effect of interleukin‐10 (IL‐10) on endotoxin‐induced TF activity and antigen levels, and on the expression of TF mRNA levels in human monocytes. These results emphasize the potential therapeutic value of this cytokine in septic shock, a condition still associated with a high mortality rate.