Effects of CCK antagonists on CCK-induced suppression of locomotor activity in mice

• DOI: 10.1016/0196-9781(92)90156-w
• Publication Date: 2003-05-01T00:30:49Z
• Authors: Yoshiaki Hirosue; Akio Inui; Masaki Miura; Masaharu Nakajima; Minoru Okita; Norio Himori; Shigeaki Baba; Masato Kasuga
• Keywords: Male; Benzodiazepinones; 0303 health sciences; Injections, Subcutaneous; Phenylurea Compounds; Mice, Inbred Strains; Motor Activity; Devazepide; Sincalide; 3. Good health; Mice; 03 medical and health sciences; Animals; Receptors, Cholecystokinin; Cholecystokinin; Injections, Intraperitoneal; Injections, Intraventricular

Sulfated cholecystokinin octapeptide (CCK-8) was administered either intraperitoneally or into the cerebral ventricle of fully conscious mice, and locomotor activity was quantified. CCK-8 administered by either route suppressed locomotor activity. Subcutaneously administered selective CCK-A receptor antagonist, L-364,718 (1 mg/kg), reversed the inhibitory effect of centrally as well as peripherally administered CCK-8, but the selective CCK-B receptor antagonist, L-365,260 (1 mg/kg), did not. These results demonstrate that centrally as well as peripherally administered CCK-8 suppresses locomotor activity in mice through an interaction with CCK-A, but not CCK-B, receptors.