α-Oligoglucosylation of a sugar moiety enhances the bioavailability of quercetin glucosides in humans

• DOI: 10.1016/j.abb.2010.06.036
• Publication Date: 2010-07-19T07:12:15Z
• Authors: Kaeko Murota; Namiko Matsuda; Yasuaki Kashino; Yutaka Fujikura; Toshiyuki Nakamura; Yoji Kato; Ryosuke Shimizu; Syuji Okuyama; Hisashi Tanaka; Takatoshi Koda; Keiko Sekido; Junji Terao
• Keywords: Glucoside; Moiety

Dietary intake of quercetin is suggested to be potentially beneficial for the prevention of various diseases. We examined the effect of alpha-oligoglucosylation of the sugar moiety of quercetin monoglucoside on its bioavailability in humans. Enzymatically modified isoquercitrin (EMIQ) was prepared by enzymatic deglycosylation and the subsequent of alpha-oligoglucosylation of quercetin 3-O-beta-rutinode (rutin). The plasma level of quercetin metabolites was instantly increased by oral intake of EMIQ and its absorption efficiency was significantly higher than that of isoquercitrin (quercetin 3-O-beta-glucoside; Q3G), and rutin. The profile of plasma quercetin metabolites after EMIQ consumption did not differ from that after Q3G consumption. The apparent log P of EMIQ indicated that EMIQ is more hydrophilic than Q3G but less than quercetin 3,4'-O-beta-diglucoside. These data indicated that enzymatic alpha-oligoglucosylation to the sugar moiety is effective for enhancing the bioavailability of quercetin glucosides in humans.