Exploring fucosylation in lung cancer: Mechanisms, diagnosis, and therapeutic strategies

• DOI: 10.1016/j.abst.2024.08.005
• Publication Date: 2024-09-02T06:06:36Z
• Authors: Saima Rafique; Wei Ge; Ziyuan Gao; Yan Chen; Jun Xia; Junhong Jiang; Shuang Yang
• Keywords: Fucosylation; Tumor progression

Lung cancer remains a global health crisis, responsible for significant morbidity and mortality. Late-stage diagnosis often limits treatment options patient survival. Therefore, identifying reliable sensitive biomarkers early detection is crucial. Glycosylation, the addition of glycans to protein/RNA/lipid, vital cellular process. Normal glycosylation regulates healthy cell function, while alterations, particularly in fucosylation sialylation, contribute lung development progression. These aberrant patterns are associated with processes such as immune modulation, migration, proliferation, cell-cell recognition. Fucosylation, specific type glycosylation, frequently altered cancer, high levels detected tumors. Understanding mechanisms behind this holds immense potential. It can pave way novel therapeutic diagnostic tools cancer. By analyzing bodily fluids, it could lead early-stage diagnosis. This review delves into initiation metastasis, proposing promising strategies target mechanisms, aiming inhibit tumor growth disease