Preoperative ketamine administration for prevention of postoperative neurocognitive disorders after major orthopedic surgery in elderly patients: A multicenter randomized blinded placebo-controlled trial

• DOI: 10.1016/j.accpm.2024.101387
• Publication Date: 2024-05-06T09:25:42Z
• Authors: Franck Verdonk; Pierre Lambert; Clément Gakuba; Anais Charles Nelson; Thomas Lescot; Fanny Garnier; Jean-Michel Const...; Danielle Saurel; Sigismond Lasocki; Emmanuel Rineau; Pierre Diemunsch; Lucas Dreyfuss; Benoît Tavernier; Lucillia Bezu; Julien Josserand; Alexandre Mebazaa; Marine Coroir; Karine Nouette-Ga...; Gerard Macouillard; Pauline Glasman; Denis Lemesle; Vincent Minville; Philippe Cuvillon; Brice Gaudilliere; Christophe Quesnel; Pierre Abdel-Ahad; Tarek Sharshar; Serge Molliex; Raphael Gaillard; Jean Mantz
• Keywords: Emergence delirium; Neurocognitive; Depression

Preventive anesthetic impact on the high rates of postoperative neurocognitive disorders in elderly patients is debated. The Prevention postOperative Cognitive dysfunction by Ketamine (POCK) study aimed to assess effect ketamine this condition.