Long-term Efficacy of Fibroid Devascularization with Ultrasound-Guided High-Intensity Focused Ultrasound

• DOI: 10.1016/j.acra.2023.10.045
• Publication Date: 2023-11-18T02:40:52Z
• Authors: Yun Zhou; Ping Chen; Xiang Ji; Taotao Sun; Yuhong Li; Jiangjing Yuan; Youguo Chen; Yuanhuan Xiong; Yudong Wang

Objective To evaluate the long-term efficacy of fibroid devascularization with ultrasound-guided high-intensity focused ultrasound (USgHIFU). Design A retrospective study. Setting A specialized hospital and two general hospitals in China. Population 117 patients with uterine fibroids Methods Treatment cells were arranged to cover the targeted vessels and then sonicated through steering the HIFU focal spots. Fibroid devascularization was assessed with the Adler grade obtained by color Doppler flow imaging (CDFI) and power Doppler imaging. The patients were followed up at 1-month, 3-month, 6-month, 1-year, 2-year and 3-year after treatment. Main outcome measures The non-perfusion volume rate (NPVR), fibroid volume shrinkage rate (FVSR), Adler Grade, symptom severity score (SSS) and uterine fibroid symptom and quality of life (UFS-QOL) were evaluated. Adverse events were recorded. Results NPVR Significant difference was observed in Adler grade, FV, FVSR, SSS and UFS-QOL before and after treatment ( p<0.001). The SSSs were reduced by 33.42% at 1-year, 42.32% at 2-year and 52.46% at 3-year after treatment. Conclusions USgHIFU-induced devascularization is a practical non-invasive treatment option for patients with uterine fibroid. Also, it can sustain long-term symptom improvements and could be attractive for patients who plan to become pregnant.