NIR irradiation-controlled drug release utilizing injectable hydrogels containing gold-labeled liposomes for the treatment of melanoma cancer

• DOI: 10.1016/j.actbio.2021.09.062
• Publication Date: 2021-10-08T04:02:57Z
• Authors: Ji Eun Won; Tae In Wi; Chan Mi Lee; Ju Hyeong Lee; Tae Heung Kang; Jeong-Won Lee; Byung Cheol Shin; YeongJoo Lee; Yeong-Min Park; Hee Dong Han
• Keywords: Therapeutic index

Drug-based chemotherapy is associated with serious side effects. We developed a chemotherapeutic system comprising chitosan hydrogel (CH-HG) containing gold cluster-labeled liposomal doxorubicin (DOX) (CH-HG-GLDOX) as an injectable drug depot system. CH-HG-GLDOX can be directly injected into tumor tissue without surgical procedure, allowing this to act reservoir for DOX. enhanced the retention time of DOX in and controlled its release response near-infrared (NIR) irradiation, resulting significant inhibition growth reduced DOX-related toxicity. The combined effect poly (D,L-lactide-co-glycolic acid) nanoparticle-based vaccines increased cytotoxic CD8+ T cell immunity, leading synergistic therapeutic efficacy. provides advanced approach local delivery DOX, Here, we suggest combination strategy chemo- immunotherapies, well nanomedicine applications. STATEMENT OF SIGNIFICANCE: liposomes sustained at site. Moreover, demonstrated efficacy immunotherapeutic vaccine melanoma cancer. Thus, show potential immunotherapies cancer treatment.