Electrically responsive release of proteins from conducting polymer hydrogels

• DOI: 10.1016/j.actbio.2023.01.013
• Publication Date: 2023-01-12T02:03:17Z
• Authors: Ernest Cheah; Mahima Bansal; Linh Nguyen; Anaïs Chalard; Jenny Malmström; Simon J. O'Carroll; Bronwen Connor; Zimei Wu; Darren Svirskis
• Keywords: Biocompatible material; Gelatin; Polypyrrole

Electrically modulated delivery of proteins provides an avenue to target local tissues specifically and tune the dose application. This approach prolongs enhances activity at site whilst reducing off-target effects associated with systemic drug delivery. The work presented here explores electrically active composite material comprising a biocompatible hydrogel, gelatin methacryloyl (GelMA) conducting polymer, poly(3,4-ethylenedioxythiophene), generating polymer hydrogel. In this paper, key characteristics electroactivity, mechanical properties, morphology are characterized using electrochemistry techniques, atomic force, scanning electron microscopy. Cytocompatibility is established through exposure human cells materials. By applying different electrical-stimuli, short-term release profiles model protein can be controlled over 4 h, demonstrating tunable patterns. followed by extended-release studies 21 days which reveal bimodal mechanism influenced both GelMA degradation electrical stimulation events. data demonstrates electroactive cytocompatible suitable for payloads 3 weeks. well suited use as treatment platform in tissue engineering applications where targeted spatio-temporal therapeutic required. Growth factor typically requires sustained generate optimal outcomes. While hydrogels (CPH) have been explored responsive small bioactives, we report on CPH capable releasing payload response stimulus. combines benefits soft acting reservoir redox-active properties from enabling responsiveness. able sustain weeks, stimulus used modulate release. described deliver large quantities patterns paramount.