Ultrasound stiffness and perfusion markers correlate with tumor volume responses to immunotherapy

• DOI: 10.1016/j.actbio.2023.06.007
• Publication Date: 2023-06-16T00:04:26Z
• Authors: Chrysovalantis Vo...; Fotios Mpekris; Myrofora Panagi; Connor Krolak; Christina Michael; John D. Martin; Michalakis A. Ave...; Triantafyllos Sty...
• Keywords: Perfusion; Tumor Microenvironment; Humans; Elasticity Imaging Techniques; Immunotherapy; Immune Checkpoint Inhibitors; Melanoma; Biomarkers; 3. Good health; Tumor Burden

Immunotherapy has revolutionized the treatment of dozens cancers and became a standard care for some tumor types. However, majority patients do not benefit from current immunotherapeutics many develop severe toxicities. Therefore, identification biomarkers to classify as likely responders or non-responders immunotherapy is timely task. Here, we test ultrasound imaging markers stiffness perfusion. Ultrasound non-invasive clinically available can be used both perfusion evaluation. In this study, employed syngeneic orthotopic models two breast cancers, fibrosarcoma melanoma, demonstrate that ultrasound-derived measures (i.e., blood volume) correlate with efficacy immune checkpoint inhibition (ICI) in terms changes primary volume. To modulate thus, get range therapeutic outcomes, mechanotherapeutic tranilast. Mechanotherapeutics combined ICI are advancing through clinical trials, but response have been tested until now. We found existence linear correlations between well strong on growth rates. Our findings set basis predictive therapy combination mechanotherapeutics. STATEMENT OF SIGNIFICANCE: Hypothesis: Monitoring Tumor Microenvironment (TME) mechanical abnormalities predict provide response. stiffening solid stress elevation hallmarks patho-physiology desmoplastic tumors. They induce hypo-perfusion hypoxia by compressing vessels, posing major barriers immunotherapy. new class drugs target TME reduce improve oxygenation. show derived shear wave elastography contrast enhanced