Vascular stent with immobilized anti-inflammatory chemerin 15 peptides mitigates neointimal hyperplasia and accelerates vascular healing

• DOI: 10.1016/j.actbio.2024.02.022
• Publication Date: 2024-02-20T02:55:44Z
• Authors: Lan Wen; Hua Qiu; Shuang Li; Yan Huang; Qiufen Tu; Nan Lyu; Xiaohui Mou; Xia Luo; Jingyu Zhou; Yin Chen; Chaohua Wang; Nan Huang; Jianguo Xu
• Keywords: Neointimal hyperplasia

Endovascular stenting is a safer alternative to open surgery for use in treating cerebral arterial stenosis and significantly reduces the recurrence of ischemic stroke, but widely used bare-metal stents (BMSs) often result in-stent restenosis (ISR). Although evidence suggests that drug-eluting are superior BMSs short term, their long-term performances remain unknown. Herein, we propose potential vascular stent modified by immobilizing clickable chemerin 15 (C15) peptides on surface suppress coagulation restenosis. Various characterization techniques an animal model were evaluate properties effects endothelial injury, platelet adhesion, inflammation. The C15-immobilized could prevent minimizing promoting physiological healing, restraining platelet-leukocyte-related inflammatory response, inhibiting smooth muscle cell proliferation migration. Furthermore, vivo studies demonstrated mitigated inflammation, suppressed neointimal hyperplasia, accelerated restoration. surface-modified, anti-inflammatory, endothelium-friendly may be benefit patients with stenosis. increasingly treatment, aiming treat stroke. But important accompanying complication Persistent inflammation has been established as hallmark ISR anti-inflammation strategies modification proved effective. Chemerin 15, resolution mediator 15-aa peptide, was active at picomolar through receptor, no need permeate membrane involved cells modulating macrophage polarization into protective phenotype, reducing factors release. implications this study C15 immobilized favors rapid re-endothelialization, exhibits inhibitory role As such, it helps decreased incidence ISR.