Left atrial cardiomyopathy: Pathophysiological insights, assessment methods and clinical implications

• DOI: 10.1016/j.acvd.2024.02.001
• Publication Date: 2024-03-01T04:28:45Z
• Authors: Sandro Ninni; Vincent Algalarrondo; Fabien Brette; Gilles Lemesle; Jérémy Fauconnier
• Keywords: Stroke; Restrictive cardiomyopathy; Dilated Cardiomyopathy

Atrial cardiomyopathy is defined as any complex of structural, architectural, contractile or electrophysiological changes affecting atria, with the potential to produce clinically relevant manifestations. Most our knowledge about mechanistic aspects atrial derived from studies investigating animal models fibrillation and tissue samples obtained individuals who have a history fibrillation. Several non-invasive tools been reported characterize in patients, which may be for predicting risk incident its related outcomes, such stroke. Here, we provide an overview pathophysiological mechanisms involved cardiomyopathy, discuss interplay these mechanisms, including aging, left pressure overload, metabolic disorders genetic factors. We clinical currently available electrocardiograms, cardiac imaging serum biomarkers. Finally, impact role fibrillation, stroke, heart failure dementia. Overall, this review aims highlight critical need definition improve treatment strategies.