Microarray analysis of differentially expressed miRNA in triple negative breast cancer: A study of western India

• DOI: 10.1016/j.adcanc.2024.100119
• Publication Date: 2024-03-22T12:45:47Z
• Authors: Hemangini Vora; Nikita Bhatt; Dharvi Shah; Prabhudas Patel; Sonia Parikh; Priti Trivedi; Shashank Pandya
• Keywords: Triple-negative breast cancer

Triple-negative breast cancer (TNBC) is a genetically and morphologically heterogeneous group with aggressive biological behaviour specific response to therapy. It accounts for 15–20% of all cancers has two subtypes: basal like non-basal like. MicroRNAs, which regulate gene expression, play role in TNBC, potentially acting as oncogenes or tumor suppressors. Identification differentially expressed miRNA potential clinical relevance TNBC patients. In this study, profiling by microarray was performed tissues 86 patients 12 healthy individual. Further, the evaluated. 2410 miRNAs were identified them 98% down-regulated, while only 2% up-regulated. Up regulation 55 observed target 16 genes. Top 5 genes CDNK1A, p53, TGFB1, APC HRAS. Of 7 ranking methods, method TGFB1 most significant hub gene. regulated expression then compared between who undergone remission developed disease relapse miR-4532 found upregulated relapse. up showed trend reduced disease-free overall survival. The down-regulated 238 involved pathogenesis progression. top five CDH1, PTEN, MYC, STAT3, VEGFA. STAT3 This study 32 novel playing suppressive TNBC. Among these miRNAs, miR-1273g-3p miR-4459 Patients down-regulation significantly ROC curve analysis indicated that successful distinguishing from controls. Our data down might have be used both diagnostic prognostic biomarker