Drugs age-of-onset as a signal of later post-traumatic stress disorder: Bayesian analysis of a census protocol

• DOI: 10.1016/j.addbeh.2021.107131
• Publication Date: 2021-10-13T22:47:36Z
• Authors: Lene L. Santos; Liana R. Netto; Patrícia Cavalcan...; Juliana L. Pereira; Breno Souza-Marques; Felipe Argolo; Sidnei B. Lira; Gabriel Fontes; Esdras C. Moreira; James C. Anthony; Karestan C. Koenen; Lucas C. Quarantini
• Keywords: Stress Disorders, Post-Traumatic; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Adolescent; Alcohol Drinking; Pharmaceutical Preparations; Humans; Bayes Theorem; Censuses; Child; 3. Good health

Individuals with PTSD have an increased risk of drug use disorders. Conversely, we aim to evaluate how early onset of alcohol, tobacco and psychoactive drugs use are associated with PTSD later in life. 2,193 brazilian young adults completed modularized assessments: The Trauma History Questionnaire, Post-Traumatic Stress Disorder Checklist-Civilian Version (PCL-C, transformed to PCL-5 through a crosswalk procedure), the Barratt Impulsivity Scale; and a survey on drug use with self-report questions about first use, current use, frequency, quantity, and interpersonal consequences. Bayesian inference and multivariate regression models were used to examine the effects on the risk of PTSD, considering different assumptions of information flow. Raw and unbiased (multivariate) estimates consistently revealed that earlier age of onset of alcohol and tobacco use increased risk for PTSD (Odds-ratios between 2.39 and 3.19 (Alcohol) and 1.82 to 2.05 (Tobacco). Among those who had PTSD (310), 10.3% (32) were very precocious at the onset age (12 to 18 years) of alcohol consumption (No-PTSD: 89 out 1883, 4.7%). Data supports a model in which age of onset effects are partially mediated by the number of trauma exposures. Early intoxication might suggest vulnerability for qualifying trauma events, or it may increase chances of exposure. Also, PTSD may be more likely to occur among trauma-exposed individuals with early intoxicating experiences due to alcohol or drug self-administration. The last possibility resonates with the idea that early intoxication might disrupt adolescent brain development, with a subsequent reduction in resilience when qualifying trauma events occur.