Modulating the immune system towards a functional chronic wound healing: A biomaterials and Nanomedicine perspective

• DOI: 10.1016/j.addr.2024.115342
• Publication Date: 2024-05-24T23:09:26Z
• Authors: Kevin Las Heras; Itxaso Garcia-Orue; Fiorenza Rancan; Manoli Igartua; Edorta Santos-Viz...; Rosa Maria Hernandez
• Keywords: Nanocarriers; Regenerative Medicine

Chronic non-healing wounds persist as a substantial burden for healthcare systems, influenced by factors such aging, diabetes, and obesity. In contrast to the traditionally pro-regenerative emphasis of therapies, recognition immune system integral role in wound healing has significantly grown, instigating an approach shift towards immunological processes. Thus, this review explores process, highlighting engagement system, delving into behaviors innate adaptive cells chronic scenarios. Moreover, article investigates biomaterial-based strategies modulation elucidating how adjustment their physicochemical properties or synergistic combination with other agents drugs, proteins mesenchymal stromal can effectively modulate different cells. Finally various based on synthetic biological nanostructures, including extracellular vesicles, finely tune natural immunomodulators therapeutic nanocarriers promising biophysical properties.