Comparison of the improvement in gastric mucosal tissue after Helicobacter pylori eradication between young and elderly people

• DOI: 10.1016/j.ajg.2023.01.005
• Publication Date: 2023-01-29T20:00:29Z
• Authors: Kazuhiro Mizukami; Masaaki Kodama; Masahide Fukuda; Yuka Hirashita; Koshiro Tsutsumi; Kensuke Fukuda; Ryo Ogawa; Kazuhisa Okamoto; Tadayoshi Okimoto; Kazunari Murakami
• Keywords: Intestinal metaplasia; Gastric antrum; Metaplasia; Atrophic gastritis

Helicobacter pylori (H. pylori) infection has been clearly shown to be a cause of gastric cancer, and the incidence cancer decrease with eradication. However, few reports have described utility eradication therapy in elderly people. Thus, an investigation focusing on how much actual histological improvement is obtained people was conducted.This retrospective study conducted using medical information patients diagnosed H. pylori-associated gastritis who underwent therapy. The assessed based changes atrophy intestinal metaplasia scores Updated Sydney system from before after We investigated rates one year long term more than five years group younger group.This included 221 (elderly 123, 98). In atrophy, higher were seen corpus antrum, cure antrum lower (p = 0.0282). With regard metaplasia, younger. observation, although elderly, improvements most about half patients.Though there obvious mucosa when performed at young age, some mucosal can expected eradication, even