Risk factors for isolation of multi-drug resistant organisms in coronavirus disease 2019 pneumonia: A multicenter study

• DOI: 10.1016/j.ajic.2021.06.005
• Publication Date: 2021-06-17T09:23:59Z
• Authors: Hyo-Ju Son; Tark Kim; Eunjung Lee; Se Yoon Park; Shinae Yu; Hyo-Lim Hong; Min-Chul Kim; Sun In Hong; Seongman Bae; Min Jae Kim; Sung-Han Kim; Ji Hyun Yun; Kyeong Min Jo; Yu-Mi Lee; Seungjae Lee; Jung Wan Park; Min Hyok Jeon; Tae Hyong Kim; Eun Ju Choo
• Keywords: Interquartile range; Stenotrophomonas maltophilia; Isolation

•Multi-drug resistant organisms (MDRO) were isolated from 8.6% of COVID-19 pneumonia.•MDROs detected 28% (13/47) among patients with culture data.•Long-term care facility stay was a risk factor for isolation organisms.•Corticosteroids use in may increase the bacterial co-infection.•Strict infection prevention strategies be needed factors. ObjectivesSuperimposed multi-drug (MDROs) co-infection can associated worse outcomes severe coronavirus disease 2019 (COVID-19), even if these managed strict airborne and contact precautions. Identifying factors MDROs is critical to treatment.MethodsAll eligible adult confirmed pneumonia 10 hospitals Republic Korea between February 2020 May retrospectively enrolled. Using this cohort, epidemiology evaluated.ResultsOf 152 patients, 47 microbial results included. Twenty isolates 13 (28%) cultured. Stenotrophomonas maltophilia (5 isolates) most common MDRO, followed by methicillin-resistant staphylococcus aureus (4 isolates). mostly sputum samples (80%, 16/20). The median time hospitalization MDRO 28 days (interquartile range, 18-38 days). In-hospital mortality higher (62% vs 15%; P = .001). Use systemic corticosteroids after diagnosis (adjusted odds ratio [aOR]: 15.07; 95% confidence interval [CI]: 2.34-97.01; .004) long-term (LTCF) before (aOR: 6.09; CI: 1.02-36.49; .048) isolation.ConclusionsMDROs data entire cohort. Previous LTCF adjunctive corticosteroid MDROs. Strict Superimposed treatment. All evaluated. Of isolation.