Neurotrophic keratitis after penetrating keratoplasty for lattice dystrophy

• DOI: 10.1016/j.ajoc.2021.101058
• Publication Date: 2021-02-26T13:22:55Z
• Authors: Larissa Gouvea; Raphael Penatti; Karolinne Maia Rocha
• Keywords: Lattice dystrophy; Ophthalmology; 03 medical and health sciences; 0302 clinical medicine; Neurotrophic keratitis; Case Report; Growth factor; RE1-994; 3. Good health

PURPOSE: To report clinical outcomes of a patient with unilateral neurotrophic keratitis following penetrating keratoplasty for lattice dystrophy treated with topical recombinant human nerve growth factor. OBSERVATIONS: A 75-year-old male with lattice dystrophy and history of herpes simplex keratitis, presented with recurrent neurotrophic ulceration in the right eye two years following penetrating keratoplasty. The patient was successfully treated with topical recombinant human nerve growth factor. CONCLUSION: Neurotrophic keratitis is a rare chronic disorder that affects quality of life due to the risk of vision loss. Topical recombinant human nerve growth factor is a novel and effective treatment option that may help improve optical quality and patient's satisfaction as shown in this case of recurrent neurotrophic keratitis.