Therapy with both magnesium sulfate and nifedipine does not increase the risk of serious magnesium-related maternal side effects in women with preeclampsia

Adult Risk Nifedipine Incidence Neuromuscular Diseases Calcium Channel Blockers 3. Good health Cohort Studies Magnesium Sulfate 03 medical and health sciences 0302 clinical medicine Pre-Eclampsia Pregnancy Case-Control Studies Injections, Intravenous Humans Drug Therapy, Combination Female Antihypertensive Agents Retrospective Studies
DOI: 10.1016/j.ajog.2004.11.059 Publication Date: 2005-07-15T09:34:03Z
ABSTRACT
Does the use of nifedipine and magnesium sulfate together increase serious magnesium-related effects?This was a retrospective chart review of women who were admitted to BC Women's Hospital and Health Centre (1997-2001) and were given intravenous magnesium sulfate for preeclampsia. Serious magnesium-related effects were compared among 162 cases who received magnesium sulfate and contemporaneous nifedipine and 215 control subjects who received magnesium sulfate and either another antihypertensive (n=32 women) or no antihypertensive (n=183 women) medication. Chi-squared test, Fisher's exact test, or the Student t test was used for data comparison between cases and each control group. A probability value of <.05 was considered statistically significant.The cases had more severe preeclampsia and a longer magnesium sulfate infusion. However, cases had no excess of neuromuscular weakness (53.1%) versus control subjects who received antihypertensive medication (53.1%; P=.99) or control subjects who received no antihypertensive medication (44.8%; P=.13) or other serious magnesium-related effects. Cases versus control subjects who received antihypertensive medication had less neuromuscular blockade (odds ratio, 0.04; 95% CI, 0.002-0.80). Cases versus control subjects who received no antihypertensive medication had less maternal hypotension (41.4% vs 53.0%; P=.04).The use of nifedipine and magnesium sulfate together does not increase the risk of serious magnesium-related effects.
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