Use of antidepressant medications during pregnancy: a multisite study

• DOI: 10.1016/j.ajog.2007.07.036
• Publication Date: 2007-10-02T07:30:49Z
• Authors: Susan E. Andrade; Marsha A. Raebel; Jeffrey Brown; Kimberly Lane; James Livingston; Denise Boudreau; Sharon J. Rolnick; Douglas Roblin; David H. Smith; Mary E. Willy; Judy A. Staffa; Richard Platt
• Keywords: Adult; Adolescent; Databases, Factual; Physician's Practice Patterns; Databases; 03 medical and health sciences; Maternal and Child Health; Drug Utilization Review; 0302 clinical medicine; Pregnancy; *Drug Utilization Review; Humans; Practice Patterns, Physicians'; Factual; Primary Care; Retrospective Studies; Depressive Disorder; Infant, Newborn; Infant; Health Maintenance Organizations; Prenatal Care; Middle Aged; Newborn; Antidepressive Agents; United States; 3. Good health; Pregnancy Complications; Serotonin Uptake Inhibitors; Female; Health Services Research; Selective Serotonin Reuptake Inhibitors

This study was undertaken to provide information on the prevalence of use of antidepressant drugs among pregnant women in the United States.A retrospective study was conducted using the automated databases of 7 health plans. Women who delivered an infant in a hospital were identified. Antidepressant drug use was evaluated assuming a gestational duration of 270 days.Among the 118,935 deliveries occurring from 2001-2005, 6.6% of women were dispensed an antidepressant during pregnancy. Antidepressant drug use increased from 2.0% in 1996 to 7.6% of deliveries in 2004 and 2005. Selective serotonin reuptake inhibitor use increased from 1.5% in 1996 to 6.4% in 2004 and 6.2% in 2005.Our finding that nearly 8% of pregnant women were prescribed antidepressants drugs during the years 2004 and 2005 highlights the importance of understanding the effects of these medications on the developing fetus and on the pregnant woman.