Chronic Alcohol Exposure Stimulates Adipose Tissue Lipolysis in Mice

• DOI: 10.1016/j.ajpath.2011.11.017
• Publication Date: 2012-01-09T14:54:04Z
• Authors: Wei Zhong; Yantao Zhao; Yunan Tang; Xiaoli Wei; Xue Shi; Wenlong Sun; Xiuhua Sun; Xinmin Yin; Xinguo Sun; Seongho Kim; Craig J. McClain; Xiang Zhang; Zhanxiang Zhou
• Keywords: Adipose triglyceride lipase; Steatosis

Alcohol consumption induces liver steatosis; therefore, this study investigated the possible role of adipose tissue dysfunction in pathogenesis alcoholic steatosis. Mice were pair-fed an alcohol or control liquid diet for 8 weeks to evaluate effects on lipid metabolism at tissue-liver axis. Chronic exposure reduced mass and adipocyte size. Fatty acid release from explants was significantly increased alcohol-fed mice association with activation triglyceride lipase hormone-sensitive lipase. induced insulin intolerance inactivated protein phosphatase 1 up-regulation tensin homolog (PTEN) suppressor cytokine signaling 3 (SOCS3). up-regulated fatty transport proteins caused accumulation liver. To define mechanistic link between loss hepatic gain, first administered heavy water 5 label triglycerides deuterium, then 2 weeks. Deposition deuterium-labeled analyzed using Fourier transform ion cyclotron spectrometry. more than a dozen molecules by up 6.3-fold. These data demonstrate time that due alcohol-induced hyperlipolysis are reverse transported deposited