Role of Collagen Matrix in Tumor Angiogenesis and Glioblastoma Multiforme Progression

• DOI: 10.1016/j.ajpath.2013.06.026
• Publication Date: 2013-08-05T20:32:03Z
• Authors: Tadanori Mammoto; Amanda Jiang; Elisabeth Jiang; Dipak Panigrahy; Mark W. Kieran; Akiko Mammoto
• Keywords: Tumor progression

Glioblastoma is a highly vascularized brain tumor, and antiangiogenic therapy improves its progression-free survival. However, current induces serious adverse effects including neuronal cytotoxicity tumor invasiveness resistance to therapy. Although it has been suggested that the physical microenvironment key role in angiogenesis progression, mechanism by which properties of extracellular matrix control glioblastoma progression not completely understood. Herein we show compaction (the process cells gather pack together cause associated changes cell shape size) human lines U87MG, U251, LN229 expression collagen types IV VI crosslinking enzyme lysyl oxidase up-regulates vitro angiogenic factor vascular endothelial growth factor. The inhibitor β-aminopropionitrile disrupts structure inhibits multiforme mouse orthotopic model. Similarly, d-penicillamine, enzymatic activity depleting intracerebral copper, also exhibits on mice. These findings suggest controlled important progression.