Myeloid-Derived IL-33 Limits the Severity of Dextran Sulfate Sodium–Induced Colitis

• DOI: 10.1016/j.ajpath.2020.11.004
• Publication Date: 2020-11-24T16:12:05Z
• Authors: Li-Yin Hung; Christopher F. Pa...; Bonnie Douglas; De’Broski R. Herbert
• Keywords: CD11c

IL-33 is an IL-1 family cytokine that signals through its cognate receptor, ST2, to regulate inflammation. Whether serves a pathogenic or protective role during inflammatory bowel disease controversial. Herein, two different strains of cell-specific conditionally deficient mice were used compare the myeloid- versus intestinal epithelial cell-derived dextran sodium sulfate-induced colitis. Data show loss CD11c-restricted exacerbated tissue pathology, coinciding with increased Il6 levels and forkhead box p3+ regulatory T cells. Surprisingly, lack had no impact on severity recovery. Thus, we myeloid-derived functionally restrains colitic disease, whereas dispensable.