Myeloid-Derived IL-33 Limits the Severity of Dextran Sulfate Sodium–Induced Colitis
CD11c
DOI:
10.1016/j.ajpath.2020.11.004
Publication Date:
2020-11-24T16:12:05Z
AUTHORS (4)
ABSTRACT
IL-33 is an IL-1 family cytokine that signals through its cognate receptor, ST2, to regulate inflammation. Whether serves a pathogenic or protective role during inflammatory bowel disease controversial. Herein, two different strains of cell-specific conditionally deficient mice were used compare the myeloid- versus intestinal epithelial cell-derived dextran sodium sulfate-induced colitis. Data show loss CD11c-restricted exacerbated tissue pathology, coinciding with increased Il6 levels and forkhead box p3+ regulatory T cells. Surprisingly, lack had no impact on severity recovery. Thus, we myeloid-derived functionally restrains colitic disease, whereas dispensable.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (33)
CITATIONS (8)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....