Developmental Dopaminergic Signaling Modulates Neural Circuit Formation and Contributes to Autism Spectrum Disorder–Related Phenotypes

• DOI: 10.1016/j.ajpath.2024.02.014
• Publication Date: 2024-03-16T05:02:19Z
• Authors: Xiaojuan Lu; Yixing Song; Jiaqi Wang; Yunyun Cai; Siwan Peng; Jiaqi Lin; Biqin Lai; Junjie Sun; Tianqing Liu; Gang Chen; Lingyan Xing
• Keywords: Neural Development; Dopaminergic pathways; Neurodevelopmental disorder

Autism spectrum disorder (ASD) is a prevalent neurodevelopmental with complex etiology. Recent evidence suggests that dopamine plays crucial role in neural development. However, it remains unclear whether and how disrupted dopaminergic signaling during development contributes to ASD. In this study, human brain RNA-seq transcriptome analysis revealed significant correlation between changes pathways developmental ASD patients. the zebrafish model, led circuit abnormalities behavior reminiscent of autism. Dopaminergic may impact neuronal specification by potentially modulating integrins. These findings shed light on mechanisms underlying link ASD, they point possibility targeting early for treatment.