Polydopamine-coated i-motif DNA/Gold nanoplatforms for synergistic photothermal-chemotherapy

• DOI: 10.1016/j.ajps.2023.100781
• Publication Date: 2023-02-01T17:49:08Z
• Authors: Bo Chen; Lan Mei; Rangrang Fan; Di Chuan; Yangmei Ren; Min Mu; Haifeng Chen; Bingwen Zou; Gang Guo
• Keywords: Aptamer; Photothermal effect

The combination of photothermal therapy with chemotherapy has gradually developed into promising cancer therapy. Here, a synergistic photothermal-chemotherapy nanoplatform based on polydopamine (PDA)-coated gold nanoparticles (AuNPs) were facilely achieved via the in situ polymerization dopamine (DA) surface AuNPs. This exhibited augmented conversion efficiency and enhanced colloidal stability comparison uncoated PDA shell i-motif DNA nanostructure was assembled PDA-coated AuNPs, which could be transformed C-quadruplex structure under an acidic environment, showing characteristic pH response. served as linker between AuNPs nanostructure. To enhance specific cellular uptake, AS1411 aptamer introduced to employed targeting ligand. In addition, Dox-loaded NPs (DAu@PDA-AS141) showed pH/photothermal-responsive release Dox. effect DAu@PDA-AS141 elicited excellent performance efficient cell inhibition 808 nm near-infrared (NIR) irradiation. Overall, these results demonstrate that shows great potential photothermal-chemotherapy.