Autophagy and mitophagy as potential therapeutic targets in diabetic heart condition: Harnessing the power of nanotheranostics

• DOI: 10.1016/j.ajps.2024.100927
• Publication Date: 2024-05-19T09:15:51Z
• Authors: Sagnik Nag; Oishi Mitra; Bhanu Maturi; Simran Preet Kaur; Ankita Saini; Muskan Nama; Soumik Roy; Souvik Samanta; Leena Chacko; Rohan Dutta; Suresh Babu Sayana; Vetriselvan Subra...; Jasvinder Singh B...; Ramesh Kandimalla
• Keywords: Diabetic Cardiomyopathy

Autophagy and mitophagy pose unresolved challenges in understanding the pathology of diabetic heart condition (DHC), which encompasses a complex range cardiovascular issues linked to diabetes associated cardiomyopathies. Despite significant progress reducing mortality rates from diseases (CVDs), failure remains major cause increased morbidity among patients. These cellular processes are essential for maintaining balance removing damaged or dysfunctional components, their involvement development disease makes them attractive targets diagnosis treatment. While variety conventional diagnostic therapeutic strategies available, DHC continues present challenge. Point-of-care diagnostics, supported by nanobiosensing techniques, offer promising alternative these scenarios. Although medications have been widely used patients, they raise several concerns regarding various physiological aspects. Modern medicine places great emphasis on application nanotechnology target autophagy DHC, offering approach delivering drugs beyond limitations traditional therapies. This article aims explore potential connections between autophagy, while also discussing promise nanotechnology-based theranostic interventions that specifically molecular pathways.