Metal-organic frameworks in oral drug delivery

• DOI: 10.1016/j.ajps.2024.100951
• Publication Date: 2024-08-23T03:17:27Z
• Authors: Aun Raza; Wei Wu
• Keywords: Oral; Bioavailability; Drug delivery; Nanotechnology; Therapeutics. Pharmacology; RM1-950; Metal-organic frameworks; VSI: Emerging Nanocarriers

Metal-organic frameworks (MOFs) offer innovative solutions to the limitations of traditional oral drug delivery systems through their unique combination metal ions and organic ligands. This review systematically examines structural properties principles MOFs, setting stage for application in delivery. It discusses various classes including those based on zirconium, iron, zinc, copper, titanium, aluminum, potassium, magnesium, assessing drug-loading capacities, biocompatibility, controlled release mechanisms. The effectiveness MOFs is illustrated case studies that highlight capabilities enhancing solubility, providing protection against harsh gastrointestinal environment, enabling precise release. addresses potential challenges, particularly toxicity concerns associated with calls further research into biocompatibility interactions biological systems. concludes by emphasizing revolutionizing delivery, highlighting critical need comprehensive harness full clinical applications.