The Prevalence of CYP2C8, 2C9, 2J2, and Soluble Epoxide Hydrolase Polymorphisms in African Americans With Hypertension

• DOI: 10.1016/j.amjhyper.2005.04.019
• Publication Date: 2005-10-02T07:07:49Z
• Authors: A DREISBACH; S JAPA; A SIGEL; M PARENTI; A HESS; S SRINOUANPRACHANH; A RETTIE; H KIM; F FARIN; L HAMM
• Keywords: Adult; Epoxide Hydrolases; Male; 0301 basic medicine; 0303 health sciences; Genotype; Middle Aged; Louisiana; Cytochrome P-450 CYP2J2; Linkage Disequilibrium; 3. Good health; Black or African American; Cytochrome P-450 CYP2C8; 03 medical and health sciences; Cytochrome P-450 Enzyme System; Gene Frequency; Case-Control Studies; Hypertension; Oxygenases; Humans; Female; Aryl Hydrocarbon Hydroxylases; Alleles; Cytochrome P-450 CYP2C9

Background:The cytochrome P450 (CYP) epoxygenase pathway produces arachidonic acid metabolites that are vasoactive, affect renal sodium handling, and have been proposed to play a mechanistic role in hypertension. Multiple single nucleotide polymorphisms (SNP) CYP2C8, 2C9, 2J2 soluble epoxide hydrolase (sEH) identified, many of which altered functional activity vitro. We performed case-control study determine the prevalence epoxygenase-related SNP African American individuals evaluate whether these associated with increased risk