Selenomethionine alleviates chronic heat stress-induced breast muscle injury and poor meat quality in broilers via relieving mitochondrial dysfunction and endoplasmic reticulum stress

• DOI: 10.1016/j.aninu.2023.12.008
• Publication Date: 2024-02-02T01:37:36Z
• Authors: Jinzhong Jing; Jiayi Wang; Xiaoyu Xiang; Shenggang Yin; Jiayong Tang; Longqiong Wang; Gang Jia; Guangmang Liu; Xiaoling Chen; Gang Tian; Jingyi Cai; Bo Kang; Lianqiang Che; Hua Zhao
• Keywords: Reticulum

In the present study, chronic heat stress (CHS) broiler model was developed to investigate potential protection mechanism of organic selenium (selenomethionine, SeMet) on CHS-induced skeletal muscle growth retardation and poor meat quality. Four hundred Arbor Acres male broilers (680 ± 70 g, 21 d old) were grouped into 5 treatments with 8 replicates 10 per replicate. Broilers in control group raised a thermoneutral environment (22 2 °C) fed basal diet. The other four exposed hyperthermic conditions (33 °C, 24 h each day) diet supplied SeMet at 0.0, 0.2, 0.4, 0.6 mg Se/kg, respectively, for d. Results showed that CHS reduced (P < 0.05) performance, decreased breast weight impaired quality broilers. induced protein metabolic disorder muscle, which increased expression caspase 3, 8, 9 ubiquitin proteasome system related genes, while P-4EBP1. also antioxidant capacity mitochondrial endoplasmic reticulum (ER) ROS levels, concentration ATP, HSP60 CLPX, ER biomarkers. Dietary supplementation linearly Se exhibited protective effects via up-regulating selenotranscriptome several key selenoproteins, body weight, improved quality, enhanced mitigated stress. What's more, suppressed degradation biosynthesis though inhibiting promoting mTOR-4EBP1 pathway. conclusion, dietary increases alleviates dysfunction stress, improves biosynthesis, suppresses degradation, thus CHS.