Radiation therapy on lentigo maligna: A single-centre retrospective study on 91 patients

• DOI: 10.1016/j.annder.2025.103342
• Publication Date: 2025-03-04T23:14:09Z
• Authors: D. Canu; R. Kabore; O. Cogrel; A. Lamoureux; E. Gerard; N. Ouhabrache; M. Beylot-Barry
• Keywords: Lentigo maligna

Lentigo maligna (LM) is a melanoma subtype that occurs on sun-damaged skin in the elderly. Dermal invasive developing from LM called (LMM) and has same prognosis as other subtypes. The standard treatment for surgery, which offers lowest risk of recurrence. Alternatives exist, however, including radiotherapy (RT). Describe real-life cohort patients with LM/LMM treated RT assess prognostic factors This retrospective monocentric study conducted Bordeaux University Hospital. All or LMM between 2009 2020 were included. was administered using superficial orthovoltage X-ray (kV) dose 40 Gy 10 fractions over 5 weeks. Ninety-one included: 67 24 LMM. Sixty-four female, mean age 77 (range: 50‑96) group, 80 56-98) group. duration post-RT follow-up 25.1 months 0-100). Fourteen recurrences observed (15.4%): group (14.9%) 4 (16.7%). Most occurred irradiation field: 8/10 2/4 Recurrences more frequent men (6/27 vs 8/64) eyelid area (4/14) compared to others locations. recurrence also higher at least one prior failure (8/36 (22.2%) 6/55 (10.9%)). There significantly fewer who had achieved complete response 3 those partial (7.1% 28.6%, p = 0.0159). Radiotherapy therapeutic alternative surgery be considered selected LM.