A smart MnO2-doped graphene oxide nanosheet for enhanced chemo-photodynamic combinatorial therapy via simultaneous oxygenation and glutathione depletion

• DOI: 10.1016/j.apsb.2020.07.021
• Publication Date: 2020-08-07T16:26:01Z
• Authors: Peng Liu; Xin Xie; Miao Liu; Shuo Hu; Jinsong Ding; Wenhu Zhou
• Keywords: Hypoxia; Tumor Hypoxia

The combination of chemotherapy and photodynamic therapy provides a promising approach for enhanced tumor eradication by overcoming the limitations each individual therapeutic modality. However, is pathologically featured with extreme hypoxia together adaptable overexpression anti-oxidants, such as glutathione (GSH), which greatly restricts efficiency. Here, combinatorial strategy was designed to simultaneously relieve self-oxygenation reduce intracellular GSH level sensitize chemo-photodynamic therapy. In our system, novel multi-functional nanosystem based on MnO2-doped graphene oxide (GO) developed co-load cisplatin (CisPt) photosensitizer (Ce6). With MnO2 doping, equipped intelligent functionalities: (1) catalyzes decomposition H2O2 into oxygen hypoxia; (2) depletes in cells, (3) concomitantly generates Mn2+ proceed Fenton-like reaction, all contribute anti-tumor efficacy. Meanwhile, surface hyaluronic acid (HA) modification could facilitate targeted delivery thereby resulting amplified cellular toxicity, well growth inhibition nude mice model. This work sheds new light development nanosystems synergistic via regulating microenvironment.