Fucoidan-functionalized activated platelet-hitchhiking micelles simultaneously track tumor cells and remodel the immunosuppressive microenvironment for efficient metastatic cancer treatment

• DOI: 10.1016/j.apsb.2021.05.012
• Publication Date: 2021-06-16T03:46:24Z
• Authors: Rong Guo; Miao Deng; Xuan He; Mengmeng Li; Jiaxin Li; Penghui He; Houqin Liu; Man Li; Zhirong Zhang; Qin He
• Keywords: Fucoidan; Circulating tumor cell

Tumor metastasis is responsible for most mortality in cancer patients, and remains a challenge clinical treatment. Platelets can be recruited activated by tumor cells, then adhere to circulating cells (CTCs) assist extravasate distant organs. Therefore, nanoparticles specially hitchhiking on platelets are considered have excellent targeting ability primary tumor, CTCs However, the tumor-homing will release transforming growth factor-β (TGF-β), which promotes forms immunosuppressive microenvironment. multitalent strategy needed balance accurate tracking alleviate signals. In this study, fucoidan-functionalized micelle (FD/DOX) was constructed, could efficiently through P-selectin. Compared with without P-selectin effect, FD/DOX had increased distribution both tissue niche, exhibited anti-tumor anti-metastasis efficacy 4T1 spontaneous model. addition, due contribution of fucoidan, treatment confirmed inhibit expression TGF-β, thereby stimulating immune response reversing The platelets-hitchhiking promising metastatic