Combination therapy using microwave ablation and d-mannose-chelated iron oxide nanoparticles inhibits hepatocellular carcinoma progression

• DOI: 10.1016/j.apsb.2022.05.026
• Publication Date: 2022-05-29T13:53:10Z
• Authors: Rui Cui; Luo Wang; Dongyun Zhang; Kun Zhang; Jianping Dou; Linan Dong; Yixuan Zhang; Jiapeng Wu; Longfei Tan; Jie Yu; Ping Liang
• Keywords: Microwave ablation; Macrophage polarization; Iron oxide nanoparticles; Tumor progression

Despite being a common therapy for hepatocellular carcinoma (HCC), insufficient thermal ablation can leave behind tumor residues that cause recurrence. This is believed to augment M2 inflammatory macrophages usually play pro-tumorigenic role. To address this problem, we designed d-mannose-chelated iron oxide nanoparticles (man-IONPs) polarize M2-like into the antitumor M1 phenotype. In vitro and in vivo experiments demonstrated man-IONPs specifically targeted accumulated peri-ablation zones after macrophage infiltration was augmented under microwave (MWA). The simultaneously induced polarization of phenotypes, enabling transformation immunosuppressive microenvironment an immunoactivating one. Post-MWA exerted robust inhibitory effects on HCC progression well-established orthotopic liver cancer mouse model. Thus, combining with salvage residual tumors MWA. These results have strong potential clinical translation.