Bio-inspired citrate functionalized apatite coating on rapid prototyped titanium scaffold

• DOI: 10.1016/j.apsusc.2014.06.113
• Publication Date: 2014-06-24T16:10:41Z
• Authors: Peng Yu; Fang Lu; Wenjun Zhu; Di Wang; Xiaojing Zhu; Guoxin Tan; Xiaolan Wang; Yu Zhang; Lihua Li; Chengyun Ning
• Keywords: Simulated body fluid; Nanoporous; Amorphous calcium phosphate

Abstract Scaffold functionalized with appropriate osteogenic coatings can significantly improve implant-bone response. In this study, with designed model and optimized manufacture parameters, reproducible and precise titanium scaffolds were produced. Reconstructed three-dimensional image and sectional structure of the scaffold were examined by micro-computed tomography and relative software. Alkali treatment was carried out on these manufactured porous scaffolds to produce nanoporous hydrophilic film. After 6 days deposition in simulated body fluid (SBF) containing sodium citrate (SC-SBF), plate-like amorphous calcium phosphate (ACP) coating was deposited on scaffold surface. Ultrasonication tests qualitatively indicated an enhanced adhesion force of apatite coatings deposited in SC-SBF compared to that deposited in SBF. And the effect of citrate ions on the CO 3 2− incorporation rate in apatite coating was quantitatively examined by bending vibration of CO 3 2− at ∼874 cm −1 . Results indicated the highest carbonate content was obtained at the citrate ion concentration of 6 × 10 −5 mol/L in SC-SBF. These three-dimensional porous titanium-apatite hybrid scaffolds are expected to find application in bone tissue regeneration.