Grandmother's pesticide exposure revealed bi-generational effects in Daphnia magna

• DOI: 10.1016/j.aquatox.2021.105861
• Publication Date: 2021-05-11T16:28:52Z
• Authors: Rikke Poulsen; Henrik H. De Fine...; Martin Hansen; Nina Cedergreen
• Keywords: Daphnia magna; Mode of Action; Maternal effect

Man-made chemicals are a significant contributor to the ongoing deterioration of numerous ecosystems. Currently, risk assessment these is based on observations in single generation animals, despite potential adverse intergenerational effects. Here, we investigate effect fungicide prochloraz across three generations Daphnia magna. We studied both effects continuous exposure over all and first-generation (F0) two subsequent generations. Effects at different levels biological organization from genome-wide gene expression, whole organism metabolite levels, CYP enzyme activity key phenotypic effects, such as reproduction, were monitored. Acclimation was found after exposure. Following F0-exposure, embryonically exposed F1-offspring showed no However, potentially germline F2 several parameters differed significantly controls. A direct association between toxic mode action found, showing that can be harmful not only directly generation, but also prenatally way may even appear skip generation. This implies current practices neglecting an important aspect toxicity, delayed due time gap chemical emergence