A Genome-Wide Association Study of Small Cell Lung Cancer

• DOI: 10.1016/j.arbres.2023.07.008
• Publication Date: 2023-07-15T01:11:36Z
• Authors: José Ramón Enjo-B...; Alberto Ruano-Ravina; Silvia Diz-de-Alm...; Raquel Cruz; Inés Quintela; Julia Rey-Brandariz; Ángel Carracedo; Karl Kelsey; Mariano Provencio; Juan Barros-Dios; Leonor Varela-Lema; Mónica Pérez-Ríos
• Keywords: Genome-wide Association Study; Genetic Association

Introduction: Small Cell Lung cancer (SCLC) comprises 10-15% of all lung cases and is the most aggressive histological type. Survival poor molecular landscape this disease extraordinarily complex. The objective paper was to perform a Genome Wide Association Study (GWAS) using case-control study specifically designed for Cancer (SCLC). Methods: Incident were consecutively recruited from 8 hospitals different regions Spain. Controls same frequency sampling based on age sex distribution cases. Biological samples obtained along with detailed information controls lifestyle, including tobacco radon exposure. Results: We included 271 SCLC 557 controls. found evidence (p-values <10-5) an association in complete dataset several loci, while MAP4 showed significant gene-based analysis. Pathway analysis suggested that ATR, ATRIP, MCM4, MCM5, ORC4, RPA3 CDC25A genes have role onset SCLC. Conclusion: This provides biological pathways related SCLC, offering novel loci further research.