Pharmacological interventions in human aging

• DOI: 10.1016/j.arr.2024.102213
• Publication Date: 2024-02-02T06:39:49Z
• Authors: Michael Angelo Petr; Frida Matiyevskaya; Brenna Osborne; Magnus Berglind; Simon Reves; Bin Zhang; Michael Ben Ezra; Lina Maria Carmon...; Muhammad Farraz S...; Marta Cortés Medi...; Guido Keijzers; Daniela Bakula; Garik V Mkrtchyan; Morten Scheibye-K...
• Keywords: Database; Aging; Clinical trials; Age-associated diseases; Small molecules; Pharmacological interventions

Pharmacological interventions are emerging as potential avenues of alleviating age-related disease. However, the knowledge of ongoing clinical trials as they relate to aging and pharmacological interventions is dispersed across a variety of mediums. In this review we summarize 136 age-related clinical trials that have been completed or are ongoing. Furthermore, we establish a database that describe the trials (AgingDB, www.agingdb.com) keeping track of the previous and ongoing clinical trials, alongside their outcomes. The aim of this review and database is to give people the ability to easily query for their trial of interest and stay up to date on the latest results. In sum, herein we give an overview of the current pharmacological strategies that have been applied to target human aging.