Lipoprotein(a) levels and atherosclerotic plaque characteristics in the carotid artery: The Plaque at RISK (PARISK) study

• DOI: 10.1016/j.atherosclerosis.2021.06.004
• Publication Date: 2021-06-11T05:08:09Z
• Authors: Dianne H.K. van D...; Anouk C. van Dijk; Geneviève A.J.C. ...; Carlo Lucci; M. Eline Kooi; Jeroen Hendrikse; Paul J. Nederkoorn; Mat J.A.P. Daemen; Antonius F.W. van...; Peter J. Koudstaal; Florian Kronenberg; Jeanine E. Roeter...; Monique T. Mulder; Aad van der Lugt
• Keywords: Lipoprotein(a); Fibrous cap

Lipoprotein(a) is an independent risk factor for cardiovascular disease and recurrent ischemic stroke. levels are known to be associated with carotid artery stenosis, but the relation of lipoprotein(a) atherosclerotic plaque composition morphology less known. We hypothesize that higher lipoprotein(a)-related SNPs a more vulnerable this effect sex-specific.In 182 patients Plaque At RISK study we determined concentrations, apo(a) KIV-2 repeats LPA SNPs. Imaging characteristics atherosclerosis were by MDCTA (n = 161) and/or MRI 171). Regressions analyses used investigate sex-stratified associations between levels, repeats, imaging characteristics.Lipoprotein(a) was presence lipid-rich necrotic core (LRNC) (aOR 1.07, 95% CI: 1.00; 1.15), thin-or-ruptured fibrous cap (TRFC) 1.01; 1.14), degree stenosis (β 0.44, 0.00; 0.88). In women, intraplaque hemorrhage (IPH) 1.25, 1.06; 1.61). men, 0.58, 0.04; 1.12). Rs10455872 significantly increased calcification volume 0.25; 1.89) absence ulceration 0.25, 0.93). T3888P LRNC 0.36, 0.16; 0.78) smaller maximum vessel wall area -10.24, 95%CI: -19.03; -1.44).In symptomatic IPH, LRNC, TRFC, as characteristics, in artery. lower prevalence area. Further research larger populations needed confirm these results.