Metabolic reprogramming of immune cells by mitochondrial division inhibitor-1 to prevent post-vascular injury neointimal hyperplasia

• DOI: 10.1016/j.atherosclerosis.2024.117450
• Publication Date: 2024-01-14T02:00:48Z
• Authors: Gustavo E. Crespo...; Sauri Hernandez-R...; Chrishan J. Ramac...; Victor Ungureanu; Ying-Hsi Lin; Shengjie Lu; Jürgen Bernhagen; Omar El Bounkari; Klaus T. Preissner; Elisa A. Liehn; Derek J. Hausenloy
• Keywords: Neointimal hyperplasia; Neointima

New treatments are needed to prevent neointimal hyperplasia that contributes post-angioplasty and stent restenosis in patients with coronary artery disease (CAD) peripheral arterial (PAD). We investigated whether modulating mitochondrial function using division inhibitor-1 (Mdivi-1) could reduce post-vascular injury by metabolic reprogramming of macrophages from a pro-inflammatory anti-inflammatory phenotype.