A collaborative effort across Africa to investigate risk factors and outcomes of premature acute coronary syndrome: Protocol for the EAS Lipid Registry of Africa (LIPRA)

• DOI: 10.1016/j.athplu.2024.10.002
• Publication Date: 2024-10-24T02:00:20Z
• Authors: Ashraf Reda; Alexander R.M. Lyons; Alberto Zambon; Ahmed Bendary; Mutaz Al-Khnifsawi; Habib Gamra; David Marais; Okechukwu S. Ogah; Tigist Seleshi; Ahmed A.A. Suliman; Julius C. Mwita; Albertino Damasceno; Anastase Dzudie; Atef Elbahry; Elsayed Farag; Chala Fekadu; Lilian Mbau; Mohammed Mujahed; Rosemary P. Minja; Bernard Samia; Mahmoud Sani; Lambert T. Appiah; Alexandros Tselepis
• Keywords: NSTEMI; EAS LIPRA; Premature acute coronary syndrome; RC666-701; Full Length Article; Diseases of the circulatory (Cardiovascular) system; Acute coronary syndrome; Cardiovascular disease risk; Acute coronary syndrome; Cardiovascular disease risk; Coronary artery disease; EAS LIPRA; NSTEMI; Premature acute coronary syndrome; STEMI; Unstable angina; Coronary artery disease

Data on acute coronary syndrome (ACS) is lacking in Africa where cases of premature ACS seem to be the rise. would benefit from an epidemiological assessment determine its risk factors and management this demographic inform guidelines practice. The European Atherosclerosis Society recognised urgency formed a growing network across 11 African countries create Lipid Registry (EAS-LIPRA). This article based EAS-LIPRA protocol presents aims, concept methodological considerations, operations collaborative governance structure project. aims report outcomes further understand prevalence via collating pooling multinational prospective data multiple sites into standardised registry. will stratified subgroups country-level income as defined by World Bank, within country residence urban versus rural areas. Valid statistical procedures employed compare observe trends pooled demographics, clinical laboratory variables, disparities management. Being first lipid registry Africa, it envisaged that expand other yet participate, facilitate studies preventive cardiology, set precedent for developing regions.