Biomolecular NMR in the AI-assisted structural biology era: Old tricks and new opportunities

• DOI: 10.1016/j.bbapap.2023.140949
• Publication Date: 2023-08-11T01:42:12Z
• Authors: Theodoros K. Kara...; Stephen Matthews
• Keywords: Structural Biology; Biomolecule; Characterization

Over the last 40 years nuclear magnetic resonance (NMR) spectroscopy has established itself as one of most versatile techniques for characterization biomolecules, especially proteins. Given molecular size limitations NMR together with recent advances in cryo-electron microscopy and artificial intelligence-assisted protein structure prediction, bright future structural biology been put into question. In this mini review we argue contrary. We discuss unique opportunities solution offers to chemist that distinguish it from all other experimental or computational methods, how can benefit machine learning.