Increased LAMP2A levels correlate with a shorter disease-free survival of HER2 negative breast cancer patients and increased breast cancer cell viability

• DOI: 10.1016/j.bbrc.2021.06.082
• Publication Date: 2021-07-03T08:44:43Z
• Authors: Igor Tokarchuk; Félice A. Janser; Anna M. Schläfli; Marta Teixeira Pinto; Magali Humbert; Nicolas J. Niklaus; Sabina Berezowska; Rupert Langer; Mario P. Tschan
• Keywords: Tissue microarray; Grading (engineering)

Chaperone Mediated Autophagy (CMA) is a selective autophagy pathway deregulated in many cancers. In this study, we were aiming at understanding the importance of CMA breast cancer. To end, examined expression markers HSP8 and LAMP2A different cancer cell lines found wide range levels across analyzed. Next, applied specific immunohistochemical staining protocol to tissue microarray derived from cohort 365 patients. Therefore, able find correlation high but not HSPA8 (HSC70) with worse disease free survival patients HER2 negative tumors (p = 0.026) which was independent prognostic parameter pT category, pN category grading multivariate model (HR 1.889; 95% CI 1.039-3.421; p 0.037). line, low decrease proliferation T47D MCF-7 vitro. Our data suggest that supports more severe phenotype.