OI inhibits development of ovarian cancer by blocking crosstalk between cancer cells and macrophages via HIF-1α pathway
Ovarian Neoplasms
Mice
0303 health sciences
03 medical and health sciences
Cell Line, Tumor
Macrophages
Animals
Humans
Female
Carcinoma, Ovarian Epithelial
Hypoxia-Inducible Factor 1, alpha Subunit
3. Good health
DOI:
10.1016/j.bbrc.2022.03.106
Publication Date:
2022-03-23T06:50:29Z
AUTHORS (5)
ABSTRACT
Intraperitoneal implantation of ovarian cancer (OC) decreases the survival rate in clinical practice. However, there are still great deficiencies in the therapeutic strategies of inhibiting the metastasis of OC. Here, we showed that 4-octyl itaconate (OI, a cell-permeable itaconate derivative) treatment didn't influence the development of OC in vitro. Instead, OI treatment repressed the activation of peritoneal macrophages and downregulated the expression of proinflammatory factors in mice bearing OC. Besides, OI inhibited the angiogenesis of OC tissues by downregulating HIF-1α of OC that was induced by proinflammatory factors from activated macrophages. In conclusion, our findings demonstrate that OI suppresses metastasis of ovarian cancer by blocking crosstalk between cancer cells and macrophages via HIF-1α pathway, providing a potential therapeutic strategy for metastasis of OC.
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CITATIONS (7)
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