The interleukin-6 signal regulates orthodontic tooth movement and pain

• DOI: 10.1016/j.bbrc.2023.09.096
• Publication Date: 2023-10-10T05:26:25Z
• Authors: Naomi Toyama; Takehito Ono; Takashi Ono; Tomoki Nakashima
• Keywords: Periodontal fiber; Bone remodeling

Orthodontic tooth movement (OTM) is accomplished by controlling the mechanical loading onto bone around roots of target teeth. The precise orthodontic force induces osteoclastic resorption on compression side and osteoblastic formation tension alveolar bone. intervention causes inflammation in periodontal ligament (PDL), which manifests as acute pain. Because deeply connected to remodeling, it has been indicated that after affects both teeth generation However, mechanisms underlying immune regulation OTM related pain are not well elucidated. Here, we found from search a public database interleukin (IL)-6 family cytokines highly expressed PDL loading. IL-6 signal was activated intervention. promoted inducing resorption. increase number osteoclasts suppressing apoptosis increasing their responsiveness macrophage colony-stimulating factor (M-CSF) receptor activator NF-κB ligand (RANKL). Furthermore, shown elicit neuroinflammation trigeminal ganglion (TG). Taken together, demonstrated regulates during treatment. It also local blockade promising therapeutic option treatment, targeting